Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
| Autor: | L. V. Pereta, I. Ya. Skrypkina, N.O. Saidakova, A.P. Onyschuk, K. V. Onyshchenko, V.M. Grygorenko, T. V. Voitsitskyi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research Fuhrman Grade 03 medical and health sciences Early-stage cancer 0302 clinical medicine Paired samples Renal cell carcinoma microRNA Biomarkers Tumor Humans Medicine miR-138 Carcinoma Renal Cell Pathological Aged business.industry Diagnostic marker Middle Aged medicine.disease Kidney Neoplasms Gene Expression Regulation Neoplastic Survival Rate body regions MicroRNAs Oncology 030220 oncology & carcinogenesis embryonic structures Cancer research Female business |
| Zdroj: | Experimental Oncology. 42 |
| ISSN: | 2312-8852 1812-9269 |
| Popis: | Aim To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and methods The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers. |
| Databáze: | OpenAIRE |
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