Cilnidipine Attenuates Renal Nerve Stimulation-Induced Renal Vasoconstriction and Antinatriuresis in Anesthetized Dogs

Autor:	Akira Takahara, Dohmoto, H., Hisa, H., Satoh, S., Yoshimoto, R.
Rok vydání:	1997
Předmět:	Male Pharmacology Dihydropyridines Sympathetic Nervous System Dose-Response Relationship Drug Angiotensin II Natriuresis Calcium Channel Blockers Kidney Electric Stimulation Norepinephrine Dogs Vasoconstriction Animals Vasoconstrictor Agents Anesthesia
Zdroj:	Scopus-Elsevier
ISSN:	0021-5198
DOI:	10.1016/s0021-5198(19)31344-7
Popis:	We examined the effects of cilnidipine, which is an L- and N-type Ca2+ channel blocker, on adrenergically regulated renal functions in anesthetized dogs. Renal nerve stimulation (RNS) at high frequency (3-7 Hz) decreased renal blood flow (RBF) without changes in systemic blood pressure. The RBF response was inhibited by intrarenal arterial (i.r.a.) infusion of cilnidipine at 0.1-0.3 microgram/kg/min. Low-frequency RNS (0.5-1 Hz) reduced absolute and fractional urinary sodium excretion. These responses were attenuated during i.r.a. infusion of cilnidipine at 0.3 microgram/kg/min. An increase in norepinephrine secretion rate induced by low-frequency RNS was also attenuated during cilnidipine infusion. These results suggest that cilnidipine can suppress norepinephrine release from the renal nerve endings and thereby interfere with the neural control of renal functions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e80d31c3d4028a34561a40bb1b9b3ee https://doi.org/10.1016/s0021-5198(19)31344-7 Zobrazit plný text záznamu