Histological chorioamnionitis and risk of pulmonary complications in preterm births: a systematic review and Meta-analysis
| Autor: | Giuseppe Maria Maruotti, Gabriele Saccone, Francesco Raimondi, Laura Sarno, Angelo Sirico, Luigi Della Corte, Fulvio Zullo, Pasquale Martinelli, Maurizio Guida |
|---|---|
| Přispěvatelé: | Sarno, L., Della Corte, L., Saccone, G., Sirico, A., Raimondi, F., Zullo, F., Guida, M., Martinelli, P., Maruotti, G. M. |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
histological chorioamnioniti fetal inflammatory response syndrome funisiti Chorioamnionitis 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Funisitis medicine Humans Prospective Studies Respiratory Distress Syndrome Newborn 030219 obstetrics & reproductive medicine Obstetrics business.industry Infant Newborn Obstetrics and Gynecology Preterm Births medicine.disease Bronchopulmonary dysplasia respiratory distress syndrome Meta-analysis Pediatrics Perinatology and Child Health Premature Birth Female Observational study business Fetal inflammatory response syndrome |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 34:3803-3812 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | Histological chorioamnionitis is associated with significant adverse maternal, perinatal and long-term outcome. We performed a meta-analysis of 30 observational studies in order to clarify the association between Histological chorioamnionitis and pulmonary complications, like respiratory distress syndrome and Bronchopulmonary Dysplasia. Unadjusted data extracted from all studies showed that Histological chorioamnionitis has no effect on development of RDS (RR 0.93, 95% CI 1.08-1.67), while it increased the risk of Bronchopulmonary Dysplasia (RR 1.75, 95% CI 1.37-2.23). However, when we restricted the analysis to the studies that adjust for Gestational Age, in order to exclude the influence of prematurity, we found that HCA reduced the risk of respiratory distress syndrome (RR 0.57, CI 95% 0.35-0.93) and it did not affect the development of Bronchopulmonary Dysplasia (RR 0.99, CI 0.76-1.3). Our results confirmed a possible role of prenatal inflammation on lung maturation. However, further prospective studies with a selected population are needed, in order to clarify the role of Histological chorioamnionitis in neonatal pulmonary complications. |
| Databáze: | OpenAIRE |
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