Predictors of chemotherapy and its effects in early stage squamous cell carcinoma of the larynx

Autor: Richard White, Larisa Greenberg, Rodney E. Wegner, Thejus T. Jayakrishnan, Athanasios Colonias
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Laryngoscope Investigative Otolaryngology, Vol 5, Iss 3, Pp 445-452 (2020)
Laryngoscope Investigative Otolaryngology
ISSN: 2378-8038
Popis: Background Squamous cell carcinoma (SCC) of larynx is a common head and neck cancer. For cases that are node negative, the role of definitive concurrent chemoradiation is unclear and not supported by guidelines but used at provider discretion. To address this knowledge gap, we examined the oncological outcomes with additional chemotherapy and factors correlated with the chemotherapy administration. Methods We queried the National Cancer Database for patients with early stage (T2N0M0) laryngeal SCC treated nonsurgically. Multivariable logistic regression identified predictors of chemotherapy. Multivariable Cox regression evaluated predictors of survival. Propensity matching accounted for indication biases. Results We identified 7181 patients meeting the eligibility criteria, of which 1568 (22%) patients received chemotherapy in addition to radiation. Predictors of chemotherapy use included younger age, Caucasian race, more remote year of treatment, higher grade, sites other than glottis, treatment at a community cancer center, and use of intensity‐modulated radiation therapy. Median overall survival was not significantly different in the two arms analyzed—65 months (95% confidence interval [CI] 60, 72months) with chemotherapy compared to 70 months without chemotherapy (95% CI 66, 75 months, P
Databáze: OpenAIRE
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