Use of exploratory factor analysis to ascertain the correlation between the activities of rheumatoid arthritis and infection by human parvovirus B19
| Autor: | Modra Murovska, Helena J Mikazane, Anda Kadiša, Svetlana Kozireva, Aivars Lejnieks, Natalja A Kakurina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Medicine (General) viruses Human parvovirus B19 Rheumatoid arthritis Exploratory factor analysis Viremia Human parvovirus Antibodies Viral Gastroenterology Arthritis Rheumatoid Parvoviridae Infections Correlation Young Adult R5-920 Internal medicine Parvovirus B19 Human Humans Medicine In patient Aged Medicine(all) Aged 80 and over biology business.industry virus diseases Middle Aged medicine.disease Immunoglobulin M Dysplasia Immunoglobulin G DNA Viral Automotive Engineering Immunology biology.protein Female Antibody Factor Analysis Statistical business |
| Zdroj: | Medicina; Volume 51; Issue 1; Pages: 18-24 Medicina Volume 51 Issue 1 Pages 18-24 Medicina, Vol 51, Iss 1, Pp 18-24 (2015) |
| ISSN: | 1648-9144 |
| DOI: | 10.1016/j.medici.2015.01.004 |
| Popis: | Background and objective: We evaluated a possible correlation between the clinical activities of rheumatoid arthritis (RA) and human parvovirus B19 (B19) infection using exploratory factor analysis (EFA). Materials and methods: RA patients were organized into two groups: 100 patients in the main groupand97intheRA(DAS28)group.Foursubgroupsweredefinedfromthemaingroupaccording to the presence or absence of certain infection-specific markers: group I comprised 43 patients whohadIgGantibodiesagainstB19 groupII,25patientswithactiveB19infection(B19-specificIgM antibodies and/or plasma viremia) group III, 19 patients with latent/persistent B19 infection (virus-specific sequences in peripheral blood leukocytes' DNA with or without B19-specific IgG antibodies), and group IV, 13 patients without infection markers. The RA(DAS28) group was divided into four subgroups similarly to the main group: group I, 35 group II, 31 group III, 19 and group IV, 12 patients. Disease-specific clinical values in both groups were analyzed employing EFA, and the RA(DAS28) group was additionally assessed using Disease Activity Score (DAS)28. Results: RA activitywashigherinpatientswhohad markersofB19infection.Thehighestactivity of RA in both study groups was in patients with latent/persistent infection. In the RA(DAS28) group, according to DAS28, the highest activity of RA was in patients with active B19 infection. Conclusions: Using EFA and DAS28, a correlation between the clinical activity of RA and B19 infectionwasconfirmed.ThesedatasuggestthatEFAisapplicableformedico-biologicalstudies. |
| Databáze: | OpenAIRE |
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