Associations of Cervicovaginal Lactobacilli With High-Risk Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia, and Cancer: A Systematic Review and Meta-Analysis
Autor: | Huiyan Wang, Xixi Chen, Ma Yan, Ruonan Li, Lijuan Wan, Weidong Zhao |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Uterine Cervical Neoplasms Cervix Uteri Cervical intraepithelial neoplasia Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Lactobacillus Lactobacillus iners Humans Immunology and Allergy Medicine Papillomaviridae Cervical cancer biology Lactobacillus crispatus business.industry Microbiota Papillomavirus Infections HPV infection Cancer Odds ratio Protective Factors Uterine Cervical Dysplasia medicine.disease biology.organism_classification 030104 developmental biology Infectious Diseases 030220 oncology & carcinogenesis Dysbiosis Female business |
Zdroj: | The Journal of Infectious Diseases. 220:1243-1254 |
ISSN: | 1537-6613 0022-1899 |
Popis: | Background Vaginal dysbiosis characterized by depleted lactobacilli is usually correlated with human papillomavirus (HPV) infection and cervical carcinogenesis, but the effect of the Lactobacillus genus and represented species on this process remains unclear. Methods PubMed, EMBASE, and CENTRAL databases were searched up to February 15, 2019. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed-effect model and Review Manager (version 5.3) for Mac. Results Eleven studies comprising 1230 cases were included. Lactobacillus spp. was associated with the decreased detection of high-risk subtype (hr)HPV infection (OR = 0.64, 95% CI = 0.48–0.87, I2 = 6%), cervical intraepithelial neoplasia (CIN) (OR = 0.53, 95% CI = 0.34–0.83, I2 = 0%), and cervical cancer (CC) (OR = 0.12, 95% CI = 0.04–0.36, I2 = 0%). At the level of Lactobacillus species, Lactobacillus crispatus, but not Lactobacillus iners, was correlated with the decreased detection of hrHPV infection (OR = 0.49, 95% CI = 0.31–0.79, I2 = 10%) and CIN (OR = 0.50, 95% CI = 0.29–0.88, I2 = 0%). Conclusions Cervicovaginal Lactobacillus spp. is associated with the decreased detection of hrHPV infection, CIN, and CC; L. crispatus may be the critical protective factor. |
Databáze: | OpenAIRE |
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