Pt/DOX Nanomotors Enhance Penetration in the Deep Tumor by Positive Chemotaxis

Autor: Haiqing Zhong, Zhentao Zhang, Yi Zhou, Linjie Wu, Peng Ke, Yiying Lu, Qi Dai, Xiaoyan Bao, Yiyi Xia, Qiyao Yang, Xin Tan, Qichun Wei, WenHong Xu, Min Han, Liang Ma
Rok vydání: 2022
Předmět:
Zdroj: ACS applied materialsinterfaces. 14(33)
ISSN: 1944-8252
Popis: Inefficient tumor penetration caused by the characteristics of tumor microenvironments is a primary obstacle to improving drug delivery efficiency, which restricts the chemotherapy drug efficacy. One such promising idea is to construct micro/nanomotors (MNMs) as an effective delivery vehicle by way of producing autonomous motion and converting exogenous stimuli or external energies from the surrounding environment into mechanical forces. In this research, the Pt/DOX nanomotor was prepared, and the enhanced diffusion and positive chemotaxis driven by substrates were verified
Databáze: OpenAIRE