Smell Impairment in Stage I‐II Obesity: Correlation with Biochemical Regulators and Clinical Aspects

Autor: Alessandro Micarelli, Simona Mrakic‐Sposta, Beatrice Micarelli, Sandro Malacrida, Ilaria Misici, Valentina Carbini, Ilaria Iennaco, Sara Caputo, Alessandra Vezzoli, Marco Alessandrini
Rok vydání: 2022
Předmět:
Zdroj: The Laryngoscope. 132:2028-2035
ISSN: 1531-4995
0023-852X
DOI: 10.1002/lary.30325
Popis: To evaluate the differences in olfactory sensitivity, nutritional habits, levels of modulators of feeding and smell, bioelectrical impedance analysis (BIA) measures and metabolic assays between two groups of participants with stage I and II obesity and reciprocal relationships between these parameters.Eighteen participants with stage I (11 female; mean age = 54.3 ± 13.1 years) and 20 participants with stage II (10 female; mean age = 54.5 ± 11.9) obesity underwent a food frequency questionnaire and Sniffin' Sticks® test battery, anthropometric parameters, and BIA measurements as well as metabolic assays (including plasma levels of leptin, insulin, ghrelin, glucose, insulin-like growth factor-1 [IGF-1] and usual laboratory parameters).The stage II obesity participants demonstrated significant higher levels of insulin and leptin and lower levels of ghrelin and IGF-1, a reduction in odor identification (OI) and in total olfactory score, and an increase in visceral and total fat percentage. Among a mosaic of multiple correlations, ghrelin was found to positively correlate with OI and leptin negatively with odor discrimination.The present study expands the notions positing the olfactory perception - and its connections with metabolic cues, foods habits and BIA measures - changes across the two most important obesity stages. This could ameliorate clinical and research deepening of obesity-related olfactory behavior with possible consequences on diagnosis, treatment and prevention of onset and development of obesity, thus opening possible future strategies involving multidisciplinary contributions.3 Laryngoscope, 132:2028-2035, 2022.
Databáze: OpenAIRE
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