Encrypted Oligonucleotide Arrays for Molecular Authentication
| Autor: | Matthew T. Holden, Lloyd M. Smith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Authentication
Sequence design 010405 organic chemistry business.industry Chemistry Distributed computing Scale (chemistry) Nucleic Acid Hybridization General Chemistry General Medicine DNA 010402 general chemistry Encryption 01 natural sciences Article 0104 chemical sciences DECIPHER Combinatorial Chemistry Techniques business Oligonucleotide Arrays Oligonucleotide Array Sequence Analysis |
| Zdroj: | ACS Comb Sci |
| Popis: | Counterfeiting is an incredibly widespread problem, with some estimates placing its economic impact above 2% of worldwide GDP. The scale of the issue suggests that current preventive measures are either technologically insufficient or too impractical and costly to be widely adopted. High-density arrays of biomolecules are explored here as security devices that can be coupled to a valuable commodity as proof of its authenticity. Light-directed DNA array fabrication technology is used to synthesize arrays that are designed to resist analysis with sequencing-by-hybridization approaches. A relatively simple sequence design strategy forces a counterfeiter to undertake a prohibitively high number of complex experiments to decipher the array sequences employed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|