BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes
| Autor: | Pierre van der Bruggen, Pascale Boel, Claude Wildmann, Thierry Boon, Pierre Coulie, Maria Luisa Sensi, Robert Brasseur, Jean-Christophe Renauld |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_treatment Molecular Sequence Data Immunology Cell Gene Expression Peptide Biology Cell Line Cancer immunotherapy Antigen Antigens Neoplasm medicine Humans Immunology and Allergy Amino Acid Sequence Cloning Molecular Melanoma neoplasms Gene chemistry.chemical_classification Lung Base Sequence Cytolysis CTL Infectious Diseases medicine.anatomical_structure chemistry Organ Specificity Cancer research T-Lymphocytes Cytotoxic |
| Zdroj: | Immunity. 2:167-175 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/s1074-7613(95)80053-0 |
| Popis: | SummarySeveral tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis. Here, we report the identification of a new gene that codes for another of these antigens. This gene, named BAGE, codes for a putative protein of 43 aa and seems to belong to a family of several genes. The antigen recognized by the autologous CTL consists of BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw* 1601 molecule. Gene BAGE is expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal tissues with the exception of testis. Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy. |
| Databáze: | OpenAIRE |
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