Equivalent uniform dose concept evaluated by theoretical dose volume histograms for thoracic irradiation
| Autor: | F. Lorchel, Pierre Aletti, Alain Noel, Y. Perrot, P. Courvoisier, J.F. Bosset, J.L. Dumas, Didier Wolf |
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| Přispěvatelé: | Laboratoire de Physique Corpusculaire - Clermont-Ferrand ( LPC ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Alexis Vautrin ( CAV ), Laboratory of Tumor and Developmental Biology, Université de Liège-CHU Sart-Tilman, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), D'Hallewin, Marie Ange, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin (CAV), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
MESH: Thoracic Neoplasms
Esophageal Neoplasms Planning target volume General Physics and Astronomy Irradiated Volume Score MESH : Models Biological MESH : Radiotherapy Conformal 030218 nuclear medicine & medical imaging [ SDV.CAN ] Life Sciences [q-bio]/Cancer 0302 clinical medicine MESH: Body Burden Relative biological effectiveness MESH : Body Burden MESH: Radiotherapy Dosage Mathematics MESH: Radiotherapy Planning Computer-Assisted MESH : Radiotherapy Dosage MESH: Relative Biological Effectiveness Radiotherapy Dosage General Medicine MESH : Thoracic Neoplasms Equivalent uniform dose 3. Good health [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biophysics MESH: Reproducibility of Results MESH : Computer Simulation 030220 oncology & carcinogenesis MESH: Esophageal Neoplasms MESH: Radiotherapy Conformal Body Burden MESH : Sensitivity and Specificity Mathematical optimization Biophysics [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biophysics [SDV.CAN]Life Sciences [q-bio]/Cancer Models Biological Sensitivity and Specificity Thoracic irradiation 03 medical and health sciences MESH: Computer Simulation Histogram Applied mathematics Humans Radiology Nuclear Medicine and imaging Computer Simulation Radiometry MESH : Relative Biological Effectiveness MESH: Humans Radiotherapy Planning Computer-Assisted MESH : Reproducibility of Results MESH : Humans MESH: Models Biological MESH: Radiometry Reproducibility of Results MESH : Radiotherapy Planning Computer-Assisted Thoracic Neoplasms MESH: Sensitivity and Specificity MESH : Esophageal Neoplasms Radiotherapy Conformal MESH : Radiometry Relative Biological Effectiveness Volume (compression) |
| Zdroj: | Physica Medica Physica Medica, Elsevier, 2007, 23 (1), pp.16-24. 〈10.1016/j.ejmp.2006.12.003〉 Physica Medica, Elsevier, 2007, 23 (1), pp.16-24. ⟨10.1016/j.ejmp.2006.12.003⟩ Physica Medica, 2007, 23 (1), pp.16-24. ⟨10.1016/j.ejmp.2006.12.003⟩ Physica Medica, Elsevier, 2007, 23, pp.16-24 |
| ISSN: | 1120-1797 |
| DOI: | 10.1016/j.ejmp.2006.12.003〉 |
| Popis: | International audience; BACKGROUND AND PURPOSE: The goal of our study was to quantify the limits of the EUD models for use in score functions in inverse planning software, and for clinical application. MATERIALS AND METHODS: We focused on oesophagus cancer irradiation. Our evaluation was based on theoretical dose volume histograms (DVH), and we analyzed them using volumetric and linear quadratic EUD models, average and maximum dose concepts, the linear quadratic model and the differential area between each DVH. RESULTS: We evaluated our models using theoretical and more complex DVHs for the above regions of interest. We studied three types of DVH for the target volume: the first followed the ICRU dose homogeneity recommendations; the second was built out of the first requirements and the same average dose was built in for all cases; the third was truncated by a small dose hole. We also built theoretical DVHs for the organs at risk, in order to evaluate the limits of, and the ways to use both EUD(1) and EUD/LQ models, comparing them to the traditional ways of scoring a treatment plan. For each volume of interest we built theoretical treatment plans with differences in the fractionation. CONCLUSION: We concluded that both volumetric and linear quadratic EUDs should be used. Volumetric EUD(1) takes into account neither hot-cold spot compensation nor the differences in fractionation, but it is more sensitive to the increase of the irradiated volume. With linear quadratic EUD/LQ, a volumetric analysis of fractionation variation effort can be performed. |
| Databáze: | OpenAIRE |
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