Hub distribution of the brain functional networks of newborns prenatally exposed to maternal depression and SSRI antidepressants

Autor:	Angela M. Muller, Janet F. Werker, Tim F. Oberlander, Ruth E. Grunau, Lynne J. Williams, Naznin Virji-Babul, Steven P. Miller, Ursula Brain, Hervé Abdi, Bruce Bjornson, Naama Rotem-Kohavi
Rok vydání:	2019
Předmět:	Adult Serotonin reuptake inhibitor media_common.quotation_subject Mothers Physiology Amygdala 03 medical and health sciences Child Development 0302 clinical medicine Gyrus Pregnancy Neural Pathways Humans Medicine Distribution (pharmacology) Temperament Depression (differential diagnoses) media_common Brain Mapping Depressive Disorder medicine.diagnostic_test business.industry Infant Newborn Brain Infant Magnetic Resonance Imaging Antidepressive Agents 030227 psychiatry Pregnancy Complications Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Prenatal Exposure Delayed Effects Female business Functional magnetic resonance imaging Insula Selective Serotonin Reuptake Inhibitors 030217 neurology & neurosurgery
Zdroj:	Depression and Anxiety. 36:753-765
ISSN:	1520-6394 1091-4269
DOI:	10.1002/da.22906
Popis:	Background Prenatal maternal depression (PMD) and selective serotonin reuptake inhibitor (SSRI) antidepressants are associated with increased developmental risk in infants. Reports suggest that PMD is associated with hyperconnectivity of the insula and the amygdala, while SSRI exposure is associated with hyperconnectivity of the auditory network in the infant brain. However, associations between functional brain organization and PMD and/or SSRI exposure are not well understood. Methods We examined the relation between PMD or SSRI exposure and neonatal brain functional organization. Infants of control (n = 17), depressed SSRI-treated (n = 20) and depressed-only (HAM-D ≥ 8) (n = 16) women, underwent resting-state functional magnetic resonance imaging at postnatal Day 6. At 6 months, temperament was assessed using Infant Behavioral Questionnaire (IBQ). We applied GTA and partial least square regression (PLSR) to the resting-state time series to assess group differences in modularity, and connector and provincial hubs. Results Modularity was similar across all groups. The depressed-only group showed higher connector hub values in the left anterior cingulate, insula, and caudate as well as higher provincial hub values in the amygdala compared to the control group. The SSRI group showed higher provincial hub values in Heschl's gyrus relative to the depressed-only group. PLSR showed that newborns' hub values predicted 10% of the variability in infant temperament at 6 months, suggesting different developmental patterns between groups. Conclusions Prenatal exposures to maternal depression and SSRIs have differential impacts on neonatal functional brain organization. Hub values at 6 days predict variance in temperament between infant groups at 6 months of age.
Databáze:	OpenAIRE
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