Influence of DRD2 polymorphisms on the clinical outcomes of opioiddependent patients on methadone maintenance therapy
| Autor: | Rusli Ismail, Zalina Zahari, Muslih Abdulkarim Ibrahim, Chee Siong Lee, Nasir Mohamad, Mohd Azhar Mohd Yasin, Yeong Yeh Lee, Soo Choon Tan, Nurfadhlina Musa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
TaqI severity of the opiate withdrawal syndrome lcsh:Analytical chemistry lcsh:RS1-441 Bioengineering General Biochemistry Genetics and Molecular Biology lcsh:Pharmacy and materia medica Pittsburgh Sleep Quality Index 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dopamine receptor D2 Internal medicine Threshold of pain medicine 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics lcsh:QD71-142 business.industry dopamine receptor d2 Cold pressor test Opiate Withdrawal Syndrome sleep quality 030206 dentistry chemistry Opioid Dopamine receptor pain sensitivity business medicine.drug |
| Zdroj: | Journal of Pharmacy and Bioallied Sciences, Vol 12, Iss 6, Pp 787-803 (2020) |
| ISSN: | 0975-7406 |
| DOI: | 10.4103/jpbs.jpbs_248_19 |
| Popis: | Introduction: Dopamine receptor D2 (DRD2) is one of the dopamine receptors that have been studied in relation to opioid dependence. It is possible, therefore, that DRD2 gene (DRD2) polymorphisms influence treatment outcomes of patients with opioid dependence. The objective of this study was to investigate the influence of DRD2 polymorphisms on the clinical outcomes of opioid-dependent patients on methadone maintenance therapy (MMT). Materials and Methods: Patients with opioid dependence (n = 148) were recruited from MMT clinics. Pain sensitivity, severity of the opiate withdrawal syndrome, and sleep quality were assessed using cold pressor test (CPT), Subjective Opiate Withdrawal Scale (SOWS-M), and Pittsburgh Sleep Quality Index (PSQI)-Malay, respectively. Deoxyribonucleic acid (DNA) was extracted from whole blood, and then was used for genotyping of Val96Ala, Leu141Leu, Val154Ile, Pro310Ser, Ser311Cys, TaqI A, -141C Ins/Del, and A-241G polymorphisms. Results: Among 148 patients, 8.1% (n = 12), 60.8% (n = 90), 27.7% (n = 41), and 29.1% (n = 43) had at least one risk allele for Ser311Cys, TaqI A, -141C Ins/Del, and A-241G polymorphisms, respectively. There were no significant differences in pain responses (pain threshold, tolerance, and intensity), SOWS, and PSQI scores between DRD2 polymorphisms. Conclusion: The common DRD2 polymorphisms are not associated with pain sensitivity, severity of the opiate withdrawal syndrome, and sleep quality in patients with opioid dependence on MMT. However, this may be unique for Malays. Additional research should focus on investigating these findings in larger samples and different ethnicity. |
| Databáze: | OpenAIRE |
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