Propagation of regulatory fluctuations induces coordinated switching of flagellar motors in chemotaxis signaling pathway of single bacteria
| Autor: | Toshinori Namba, Tatsuo Shibata |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Statistics and Probability Regulator Cooperativity Flagellum Bacterial Physiological Phenomena Models Biological General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Motion Escherichia coli Brownian motion Physics General Immunology and Microbiology Computer simulation Bacteria Applied Mathematics Chemotaxis Molecular Motor Proteins General Medicine Models Theoretical 030104 developmental biology Cytoplasm Flagella Modeling and Simulation Biophysics Signal transduction General Agricultural and Biological Sciences Signal Transduction |
| Zdroj: | Journal of theoretical biology. 454 |
| ISSN: | 1095-8541 |
| Popis: | The random motion of E. coli is driven by multiple flagella motors. When all motors rotate in the counter clockwise direction, the bacteria swims smoothly. A recent experimental report by Terasawa et al. [Biophys J,100,2193,(2011)] demonstrated that a coordination of the motors can occur through signaling pathways, and perturbation of a regulatory molecule disrupted the coordination. Here, we develop a mathematical model to show that a large temporal fluctuation in the regulator concentration can induce a correlated switching of the multiple motors. Such a large fluctuation is generated by a chemotaxis receptor cluster in unilateral cell pole, which then exhibits a spatial propagation through the cytoplasm from the receptor position to the motor around cell periphery. Our numerical simulation successfully reproduces synchronized switching and the lag time in the motions of two distant motors, which has been observed experimentally. We further show that the large fluctuation in the regulator concentration at the motor positions can expand the dynamic range that the motor can respond, which confers robustness to the signaling system. |
| Databáze: | OpenAIRE |
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