Glucolipsin A and B, two new glucokinase activators produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii
| Autor: | Regina Ezekiel, Steven E. Klohr, Robert Hugill, Dolores M. Pirnik, Stella Huang, Judy A. Veitch, Jerzy Golik, Tomokazu Ueki, Susan P. Manly, Kasim A. Mookhtiar, Jingfang Qian-Cutrone, Susan E. Lowe, Jeffrey L. Whitney, Steven S. Kalinowski, Karen S. Brown |
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| Rok vydání: | 1999 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Spectrometry Mass Fast Atom Bombardment Disaccharides Streptomyces Nocardia Drug Discovery Glucokinase Pharmacology chemistry.chemical_classification biology Streptomycetaceae Hydrolysis Biological activity biology.organism_classification Nocardiaceae Enzyme Activation Enzyme chemistry Biochemistry Fermentation Spectrophotometry Ultraviolet Actinomycetales |
| Zdroj: | The Journal of antibiotics. 52(3) |
| ISSN: | 0021-8820 |
| Popis: | During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acyl CoA esters (FAC), two novel compounds, glucolipsin A (1) and B (2) were isolated from the butanol extracts of Streptomyces purpurogeniscleroticus WC71634 and Nocardia vaccinii WC65712, respectively. The structures of these two compounds were established by spectroscopic methods and chemical degradation. Glucolipsin A (1) and B (2) relieved the inhibition of glucokinase by FAC with RC50 values of 5.4 and 4.6 microM. |
| Databáze: | OpenAIRE |
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