Major plasma proteins in pig serum during postnatal development
| Autor: | A. Pi, N. Gonz Am, F. Lampreave, Miguel Ángel Ballesteros Martín, M. A. Tesouro |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Swine Endocrinology Pregnancy Internal medicine Genetics medicine Animals Molecular Biology Serum Albumin Radial immunodiffusion chemistry.chemical_classification biology Haptoglobins Haptoglobin Albumin Acute-phase protein Transferrin Blood Proteins Orosomucoid Fetuin Blood proteins Reproductive Medicine chemistry Animals Newborn Immunoglobulin G alpha 1-Antitrypsin biology.protein Animal Science and Zoology Female alpha-Fetoproteins Glycoprotein Developmental Biology Biotechnology Acute-Phase Proteins |
| Zdroj: | Reproduction, fertility, and development. 17(4) |
| ISSN: | 1031-3613 |
| Popis: | The time-course of changes in the levels of albumin, alpha-fetoprotein (AFP), alpha(1)-protease inhibitor (alpha(1)-antitrypsin), alpha(1)-acid glycoprotein, fetuin, haptoglobin, transferrin, IgG and the major acute-phase protein (Pig-MAP) in the blood sera of pigs during the first days and weeks of life was investigated by quantitative radial immunodiffusion. The serum of newborn pigs before suckling was characterised by a very low concentration of total proteins (approximately 25 mg mL(-1)), low levels of albumin and transferrin and the lack of immunoglobulins. In contrast, alpha(1)-acid glycoprotein and fetuin are present at high levels (approximately 12 and 5 mg mL(-1) respectively). The results of the present study show that the piglets undergo a very rapid metabolic maturation with regard to serum proteins, evolving from a characteristic 'fetal' pattern to an 'adult' one. We have paid special attention to the evolution of haptoglobin and Pig-MAP, which are two important acute-phase proteins in pigs. The evolution of serum levels of these proteins suggests that piglets must overcome a moderate acute-phase situation during the first week of life. |
| Databáze: | OpenAIRE |
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