Comparison of Stereotactic Body Radiation Therapy and Radiofrequency Ablation in the Treatment of Intrahepatic Metastases
| Autor: | Latifa Bazzi, Yebin Tao, D.R. Wahl, Mishal Mendiratta-Lala, William C. Jackson, Dawn Owen, Mary Feng, Theodore S. Lawrence, Kyle C. Cuneo, Matthew J. Schipper |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Radiofrequency ablation Stereotactic body radiation therapy Radiosurgery Article 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Primary outcome law medicine Humans Radiology Nuclear Medicine and imaging Single institution Aged Proportional Hazards Models Aged 80 and over Analysis of Variance Radiofrequency Ablation Radiation Proportional hazards model business.industry Liver Neoplasms Middle Aged Progression-Free Survival Tumor Burden Survival Rate Oncology Treatment modality 030220 oncology & carcinogenesis Female Radiology business Follow-Up Studies |
| Zdroj: | International journal of radiation oncology, biology, physics. 100(4) |
| ISSN: | 1879-355X |
| Popis: | PURPOSE: Stereotactic body radiation therapy (SBRT) and radiofrequency ablation (RFA) are widely used therapies for the treatment of intrahepatic metastases; however, direct comparisons are lacking. We sought to compare outcomes for these 2 modalities. METHODS AND MATERIALS: From 2000 to 2015, 161 patients with 282 pathologically diagnosed unresectable liver metastases were treated with RFA (n = 112) or SBRT (n = 170) at a single institution. The primary outcome was freedom from local progression (FFLP). The effect of treatment and covariates on FFLP was modeled using a mixed-effects Cox model with application of inverse probability treatment weighting to adjust for potential imbalances in treatment modality. RESULTS: The median follow-up period was 24.6 months. Patients receiving SBRT had larger tumors than those treated with RFA (median, 2.7 cm vs 1.8 cm; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|