Effect of Benzophenone-3 to Acetylcholinesterase and Antioxidant System in Zebrafish (Danio rerio) Embryos
| Autor: | Gabriela Rodríguez-Fuentes, Karla S. Escalante-Herrera, Juan José Sandoval-Gío, Elsa Noreña-Barroso |
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| Rok vydání: | 2021 |
| Předmět: |
Embryo
Nonmammalian animal structures Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment 010501 environmental sciences Toxicology 01 natural sciences Antioxidants Superoxide dismutase Andrology Benzophenones chemistry.chemical_compound medicine Animals Zebrafish 0105 earth and related environmental sciences chemistry.chemical_classification biology Superoxide Dismutase Glutathione peroxidase Neurotoxicity 04 agricultural and veterinary sciences General Medicine Glutathione medicine.disease biology.organism_classification Pollution Acetylcholinesterase Oxidative Stress chemistry Catalase embryonic structures 040103 agronomy & agriculture biology.protein 0401 agriculture forestry and fisheries Water Pollutants Chemical |
| Zdroj: | Bulletin of Environmental Contamination and Toxicology. 107:814-819 |
| ISSN: | 1432-0800 0007-4861 |
| Popis: | Benzophenone-3 (BP-3) is one of the most used UV filters. The present study aimed to evaluate the toxic effects of BP-3 during embryo stages of zebrafish four hours post-fertilization (4hpf). Embryos were exposed to 0, 1, and 10 µg L−1 of BP-3 for 72 h. We investigated biochemical and molecular biomarkers of neurotoxicity (AChE) and the antioxidant system (gene expression of catalase, CAT, superoxide dismutase, SOD, glutathione peroxidase, GPX, the concentration of total glutathione, GSH, and lipid hydroperoxides, LPO). Results indicated that the acute exposure to BP-3 in zebrafish embryos did not show significant differences in survival, hatching rate, or antioxidant system biomarkers. In contrast, there were significant differences associated with AChE gene expression and activity. |
| Databáze: | OpenAIRE |
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