Mechanism underlying the regulation of sortilin expression and its trafficking function
| Autor: | Yun-Cheng Lv, Wei Xie, Shuhui Ouyang, Jing Yang, Bo Jia |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Physiology Clinical Biochemistry Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Transcription (biology) Cell Movement microRNA Animals Humans RNA Messenger Transcription factor Messenger RNA Proteins SORT1 gene Cell Biology DNA Cell biology Adaptor Proteins Vesicular Transport Protein Transport 030104 developmental biology chemistry 030220 oncology & carcinogenesis RNA splicing DNA methylation |
| Zdroj: | Journal of cellular physiologyREFERENCES. 235(12) |
| ISSN: | 1097-4652 |
| Popis: | This review summarizes and analyzes the updated information on the regulation of sortilin expression and its trafficking function. Evidence indicates that the expression and function of sortilin are closely regulated at four levels: DNA, messenger RNA (mRNA), protein, and trafficking function. DNA methylation, several mutations, and minor single-nucleotide polymorphisms within DNA fragments affect the expression of SORT1 gene. A few transcription factors and microRNAs modulate its transcription as well as the splicing or stability of the mRNA. Moreover, several translation factors control the synthesis of sortilin protein, and posttranslational modifications affect its degradation processes. Multiple adaptor molecules modulate the sortilin trafficking function in the anterograde or retrograde pathway. Recent advances in the regulation of sortilin expression and function, and its related mechanisms will help the ongoing research related to sortilin and promote future clinical application via sortilin intervention. |
| Databáze: | OpenAIRE |
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