DExD/H-box proteins and their partners: helping RNA helicases unwind
| Autor: | Ren-Jang Lin, Gretchen Edwalds-Gilbert, Edward Silverman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Genetics
Sequence Homology Amino Acid biology RNA-induced silencing complex RNA Splicing Amino Acid Motifs Molecular Sequence Data Helicase RNA General Medicine Non-coding RNA RNA Helicase A RNA silencing eIF4A biology.protein Animals Humans Nucleic Acid Conformation Amino Acid Sequence Degradosome RNA Helicases |
| Zdroj: | Gene. 312:1-16 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/s0378-1119(03)00626-7 |
| Popis: | Members of the DExD/H-box family of RNA helicases are involved in many processes and complexes within the cell. While individual DExD/H helicase family members have been studied extensively, the mechanisms through which helicases affect multiprotein complexes are just beginning to be investigated. Because RNA helicases are both highly conserved and numerous in the cell, study of RNA helicase recruitment and modulation by cofactors is necessary for understanding the mechanisms of helicase action in vivo. This review will focus on cofactor-mediated regulation of helicase target specificity and activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect