Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives
| Autor: | Chun-Xian He, Na Yang, Min Li, Jing Wang, Bo Cao, Pengfei Yu, Maosheng Cheng, Hong Chen, Zhi-Yong Lei |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry In vitro cytotoxicity Tetrazolium Salts Colorimetry (chemical method) Podophyllotoxin derivatives Tubulin Cell Line Tumor Drug Discovery medicine Humans Cytotoxicity Podophyllotoxin Chemistry Rhodamines General Chemistry General Medicine Nuclear magnetic resonance spectroscopy Antineoplastic Agents Phytogenic Drug Resistance Multiple Thiazoles Design synthesis Drug Resistance Neoplasm Drug Design Colorimetry Drug Screening Assays Antitumor Human cancer medicine.drug |
| Zdroj: | Chemicalpharmaceutical bulletin. 56(6) |
| ISSN: | 0009-2363 |
| Popis: | A series of novel podophyllotoxin derivatives were designed using association strategy and synthesized by coupling either podophyllotoxin (1) or 4beta-amino podophyllotoxin (3) with substituted indol-3-yl-glyoxyl chlorides. Their structures were identified using spectroscopic techniques. These novel derivatives have been evaluated for cytotoxicity in vitro against four human cancer cell lines with comparison to the parent compounds 1, 3 and indibulin (2). Some of the compounds (7a, 7c) showed comparable cytotoxicity to that of podophyllotoxin. |
| Databáze: | OpenAIRE |
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