Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells
| Autor: | Eric A. Lee, Mahadeo A. Sukhai, Leonard Angka, Elliott M. McMillan, Thomas Hanlon, Paul A. Spagnuolo, Mark D. Minden, Joe Quadrilatero, Sarah G. Rota |
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| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Programmed cell death Time Factors Cell Survival chemistry.chemical_element Antineoplastic Agents Apoptosis Mice SCID Calcium Biology Mice Mice Inbred NOD hemic and lymphatic diseases Cell Line Tumor Tumor Cells Cultured Animals Humans neoplasms Cell Proliferation Dose-Response Relationship Drug Calpain Calcium channel Psychosine Myeloid leukemia Xenograft Model Antitumor Assays Tumor Burden Haematopoiesis Leukemia Myeloid Acute Oncology Biochemistry chemistry Cell culture biology.protein Cancer research Calcium Channels Signal Transduction |
| Zdroj: | Cancer letters. 348(1-2) |
| ISSN: | 1872-7980 |
| Popis: | To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively toxic toward AML cell lines and primary AML patient samples with no effect toward normal hematopoietic cells. It delayed tumor growth and reduced tumor weights in mouse xenograft models without imparting toxicity. Glucopsychosine increased cytosolic calcium and induced apoptosis through calpain enzymes. Extracellular calcium was functionally important for glucopsychosine-induced AML cell death and surface calcium channel expression is altered in AML cells highlighting a unique mechanism of glucopsychosine’s selectivity. |
| Databáze: | OpenAIRE |
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