Study of cytotoxicity performance of carbon nanohorns by method of spin probes
| Autor: | Alexander V. Okotrub, N. T. Kartel, L. V. Ivanov, A. N. Lyapunov, O. A. Gurova, Emmanuel Flahaut, Ya. O. Cherkashina |
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| Přispěvatelé: | Chuiko Institute of Surface Chemistry, National Academy of Sciences of Ukraine (NASU), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Nikolaev Institute of Inorganic Chemistry [Novosibirsk] (NIC), Siberian Branch of the Russian Academy of Sciences (SB RAS), Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Nikolaev Institute of Inorganic Chemistry - NIIC SB RAS (RUSSIA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), National Academy of Sciences of Ukraine (UKRAINE), Centre Interuniversitaire de Recherche et d'Ingénierie des Matériaux - CIRIMAT (Toulouse, France) |
| Rok vydání: | 2020 |
| Předmět: |
Matériaux
Cytotoxicity Serum albumin chemistry.chemical_element 02 engineering and technology 010402 general chemistry 01 natural sciences [SPI.MAT]Engineering Sciences [physics]/Materials Matrix (chemical analysis) Microviscosity Viscosity The method of spin probes Carbon nanohorns General Materials Science Physical and Theoretical Chemistry Erythrocyte membranes biology Chemistry Organic Chemistry 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics 0104 chemical sciences Membrane Biophysics biology.protein 0210 nano-technology Carbon |
| Zdroj: | Fullerenes, Nanotubes and Carbon Nanostructures Fullerenes, Nanotubes and Carbon Nanostructures, Taylor & Francis, 2020, 28 (9), pp.1-8. ⟨10.1080/1536383X.2020.1757656⟩ |
| ISSN: | 1536-4046 1536-383X |
| DOI: | 10.1080/1536383x.2020.1757656 |
| Popis: | International audience; The effects of as-produced and treated by HNO3(3M) carbon nanohorns on the microviscosity of rat erythrocyte membranes and the viscosity of the water-containing plasma protein matrix were investigated by the method of spin probes. Addition of nanohorns at the concentration of 100 μg/ml to a suspension of erythrocytes led to an increase in membrane microviscosity during 4 h (about 60% effect). In addition, it was shown that nanohorns also induced an increased polarity of the microenvironment for lipophilic probes in the outer layer of membrane phospholipids, as well as disorders in erythrocytes membranes. Addition of nanohorns to plasma led to a little decrease in the viscosity of water and protein matrix, apparently, due to its partial destruction, impacting especially albumin. Pristine and treated by HNO3(3M) acid nanohorns was found more cytotoxic than nanoparticles of oxidized graphene, and significantly less than carbon nanotubes, which are known to dramatically increase the microviscosity of the membranes of erythrocytes and disrupt their integrity. |
| Databáze: | OpenAIRE |
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