| Popis: |
So far as it has been possible to determine, the heptadienecarboxylic acid (diallylacetic acid) salt of bismuth was introduced into therapeutics as "medobis" in 1937. It was said to be effective in the treatment of infections of the upper part of the respiratory tract both by intramuscular and rectal administration, and no toxic manifestations were reported. 1 The first mention of its use in the United States was in 1943, 2 at which time it was recommended for the treatment of tonsillitis, pharyngitis and gingivostomatitis. Its efficacy and lack of toxicity were subsequently affirmed in two other publications. 3 Because these reports fail to mention serious illness or death after the use of "analbis" suppositories, 4 the following 4 cases, 3 of them with autopsy observations, are submitted. REPORT OF CASES Case 1.— This acutely ill white girl, aged 27 months, was admitted to Norwalk General Hospital at 2: 10 |
