Accuracy of the 2008 Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Children
| Autor: | Vanessa Crujeiras Martínez, Ecaterina Julio Tatis, José Vicente Arcos-Machancoses, María Victoria Bovo, Javier Juamperez Goñi, Jesus Quintero Bernabeu, Cristina Molera Busoms, Javier Martín de Carpi |
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| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty Hepatology Receiver operating characteristic business.industry Concordance Gastroenterology Autoimmune hepatitis medicine.disease Liver disorder 03 medical and health sciences Sensitivity and specificity 0302 clinical medicine 030220 oncology & carcinogenesis Diagnosis Pediatrics Perinatology and Child Health Cohort medicine Original Article 030211 gastroenterology & hepatology Sampling (medicine) Medical diagnosis business Area under the roc curve |
| Zdroj: | Pediatric Gastroenterology, Hepatology & Nutrition |
| ISSN: | 2234-8840 2234-8646 |
| Popis: | Purpose Classical criteria for diagnosis of autoimmune hepatitis (AIH) are intended as research tool and are difficult to apply at patient's bedside. We aimed to study the accuracy of simplified criteria and the concordance with the expert diagnosis based on the original criteria. Methods A cohort of children under study for liver disorder was selected through consecutive sampling to obtain the prevalence of AIH within the group of differential diagnoses. AIH was defined, based on classical criteria, through committee review of medical reports. Validity indicators of the simplified criteria were obtained in an intention to diagnose approach. Optimal cut-off and the area under the receiver operating characteristic (ROC) curve were calculated. Results Out of 212 cases reviewed, 47.2% were AIH. For the optimal cut-off (6 points), the simplified criteria showed a sensitivity of 72.0% and a specificity of 96.4%, with a 94.7% positive and a 79.4% negative predictive value. The area under the ROC curve was 94.3%. There was a good agreement in the pre-treatment concordance between the classical and the simplified criteria (kappa index, 0.775). Conclusion Simplified criteria provide a moderate sensitivity for the diagnosis of AIH, but may help in indicating treatment in cases under suspicion with 6 or more points. |
| Databáze: | OpenAIRE |
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