Transcerebral net exchange of vasoactive peptides and catecholamines during lipopolysaccharide-induced systemic inflammation in healthy humans
| Autor: | Damian M. Bailey, Kirsten Møller, Sarah Taudorf, Rasmus H. Dahl, Carsten Lundby, Ronan M. G. Berg |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Lipopolysaccharides Male medicine.medical_specialty Lipopolysaccharide Physiology Calcitonin Gene-Related Peptide Calcitonin gene-related peptide Systemic inflammation Norepinephrine (medication) 03 medical and health sciences chemistry.chemical_compound Catecholamines 0302 clinical medicine Physiology (medical) Internal medicine medicine Humans Pharmacology Endothelin-1 business.industry Brain 030208 emergency & critical care medicine General Medicine Endothelin 1 Healthy Volunteers Systemic Inflammatory Response Syndrome Epinephrine Endocrinology Cerebral blood flow chemistry Vasoconstriction medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 96:313-316 |
| ISSN: | 1205-7541 0008-4212 |
| Popis: | The systemic inflammatory response triggered by lipopolysaccharide (LPS) is associated with cerebral vasoconstriction, but the underlying mechanisms are unknown. We therefore examined whether a 4-hour intravenous LPS infusion (0.3 ng·kg−1) induces any changes in the transcerebral net exchange of the vasoactive peptides endothelin-1 (ET-1) and calcitonin-gene related peptide (CGRP) and catecholamines in human volunteers. Cerebral blood flow was measured by the Kety–Schmidt technique, and paired arterial-to-jugular venous blood samples were obtained for estimating the transcerebral exchange of ET-1, CGRP, and catecholamines by the Fick principle in 12 volunteers before and after LPS infusion. The cerebrovascular release of ET-1 was enhanced, whereas the transcerebral net exchange of CGRP and catecholamines was unaffected. Our findings thus point towards locally produced ET-1 within the cerebrovasculature as a contributor to cerebral vasoconstriction after LPS infusion. |
| Databáze: | OpenAIRE |
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