RAS Genetic Variants in Interaction with ACE Inhibitors Drugs Influences Essential Hypertension Control
| Autor: | Farzad Heidari, Siti Zubaidah Mohd Ali, Ramachandran Vasudevan, Mohammad Arkani, Patimah Ismail |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Genotype Population Angiotensin-Converting Enzyme Inhibitors Blood Pressure 030204 cardiovascular system & hematology Pharmacology Essential hypertension Polymorphism Single Nucleotide Renin-Angiotensin System 03 medical and health sciences 0302 clinical medicine Enalapril Lisinopril Internal medicine Renin–angiotensin system Humans Medicine Allele education Alleles education.field_of_study business.industry General Medicine Middle Aged medicine.disease Cross-Sectional Studies 030104 developmental biology Endocrinology Blood pressure Case-Control Studies Hypertension Female Gene polymorphism Essential Hypertension business medicine.drug |
| Zdroj: | Archives of Medical Research. 48:88-95 |
| ISSN: | 0188-4409 |
| DOI: | 10.1016/j.arcmed.2017.03.003 |
| Popis: | Backgrounds and Aims Essential Hypertension (EH) is a common disorder associated with increased cardiovascular morbidity and mortality in Malaysia. To investigate how genetic polymorphisms of the renin-angiotensin-aldosterone system (RAS) influence EH control with angiotensin-converting enzyme inhibitor drugs (ACEI). Methods A case–control, cross-sectional population-based nested study (n = 142) included hypertensive subjects treated with ACEI drugs, either lisinopril or enalapril (20 mg, once daily) as monotherapy for 24 weeks. In total seven possible polymorphisms of RAS genes were genotyped. The association between those polymorphisms and the changes in blood pressure were observed in the 24 week treatment. Results Statistically significant associations of I, G, T, M and G alleles of ACE (I/D, G2350A), AGT (M235T, T175M and G-6A) respectively were observed in essential hypertensive subjects. The decrease in systolic blood pressure and diastolic blood pressure after 24 weeks of treatment of the patients carrying II, GG, and TT genotypes were greater than the groups carrying DD, AA, MM, MM and GG of I/D, G2350A, M235T, T174M and G-6A genotypes respectively. In contrast, No significant difference was observed between renin gene polymorphisms (Bg/I and MboI) and hypertensives. Conclusions Although this study shows a possible association of polymorphisms of RAS genes with the risk of non-control of HT in ACEI-treated patients and indicates the importance of all this system's components in regulating HT, it needs to be replicated in other data sources. |
| Databáze: | OpenAIRE |
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