Subcutaneous antifungal screening of Latin American plant extracts againstSporothrix schenckiiandFonsecaea pedrosoi

Autor:	Isabel Gaitán, Giselle Tamayo, Roberto Pinzón, Mahabir P. Gupta, Susana Zacchino, Alberto Giménez, Armando Cáceres, Ana Margarita Paz
Rok vydání:	2011
Předmět:	Fonsecaea Antifungal Agents Drug Evaluation Preclinical Pharmaceutical Science Tecoma stans Context (language use) Microbial Sensitivity Tests Ascomycota Amphotericin B Drug Discovery Humans Sporothrix schenckii Pharmacology Ethanol biology Apocynaceae Traditional medicine Plant Extracts Sporothrix Fungi General Medicine Asteraceae biology.organism_classification Fonsecaea pedrosoi Latin America Mycoses Complementary and alternative medicine Terminalia Molecular Medicine Medicine Traditional Mitosporic Fungi Phytotherapy Plumeria rubra
Zdroj:	Pharmaceutical Biology. 49:907-919
ISSN:	1744-5116 1388-0209
Popis:	Subcutaneous mycoses are chronic infections caused by slow growing environmental fungi. Latin American plants are used in folk medicine to treat these afflictions. Moreover, the potential of the rich Latin American biodiversity for this purpose has not been fully explored.The aim of the study was to screen Latin American plant extracts against two species of subcutaneous fungi: Sporothrix schenckii and Fonsecaea pedrosoi.One hundred ninety-five organic extracts from 151 Latin American plants were screened against two subcutaneous fungi by the agar dilution method at a concentration of 100 µg/mL, and minimum inhibitory concentrations (MICs) of active extracts were determined. Positive (amphothericin B) and negative (50% ethanol) controls were used.Twenty eight extracts showed activity at ≤100 µg/mL. Of these, four extracts from Gnaphalium gaudichaudianum DC (Asteraceae), Plumeria rubra L (Apocynaceae), Tecoma stans (L.) Juss. ex Kunth. (Bignoniaceae), and Trichostigma octandum (L.), H. Walter showed activity against F. pedrosoi at MIC 12.5 µg/mL; and, four extracts from Bourreria huanita (Lex.) Hemsl. (Boraginaceae), Phytolacca bogotensis Kunth (Phytolaccaceae), Monnina xalapensis Kunth (Polygalaceae) and Crataegus pubescens (C. Presl) C. Presl (Rosaceae) against S. schenckii. This is the first report on antifungal activity of the Latin American plants against these two subcutaneous fungi.S. schenkii and F. pedrosoi were inhibited by B. huanita (MIC: 12.5 and 25 µg/mL), G. gaudichaudianum (MIC: 50 and 12.5 µg/mL) and T. triflora (MIC: 25 µg/mL).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5f3cbb678bbdf06bf59f3c16c23987 https://doi.org/10.3109/13880209.2011.555916 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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