Association Between Cognitive Function and Plasma Lipids of the Elderly After Controlling for Apolipoprotein E Genotype
| Autor: | Chiine Kodama, Fumio Yamashita, Chiaki Ikejima, Shin Hidaka, Megumi Sasaki, Takashi Asada, Fumihiko Yasuno, Katsuyoshi Mizukami, Satoshi Tanimukai, Makoto Michikawa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Apolipoprotein E Aging medicine.medical_specialty Genotype Lipoproteins Apolipoprotein E4 Neuropsychological Tests chemistry.chemical_compound Apolipoproteins E Cognition High-density lipoprotein Internal medicine medicine Humans Dementia Triglycerides Aged Triglyceride business.industry Confounding medicine.disease Psychiatry and Mental health Cholesterol Endocrinology chemistry Low-density lipoprotein Female lipids (amino acids peptides and proteins) Geriatrics and Gerontology business Lipoprotein |
| Zdroj: | The American Journal of Geriatric Psychiatry. 20:574-583 |
| ISSN: | 1064-7481 |
| Popis: | Objective Although the relationship between cognitive function and plasma lipids has attracted attention, previous studies have shown conflicting results. One possible confounding factor is due to the influence of gene-related modulator. We investigated the relationship between cognitive function and lipid plasma levels of old age after controlling for apolipoprotein E ( APOE ) genotype. Methods One thousand three hundred ninety-five subjects without dementia age 65 and older participated in this study. They were divided into two groups, with and without APOE4 [E4 (+) and E4 (−)]. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and apolipoprotein E (apoE) were measured. Associations between plasma concentrations of lipids and cognitive function were investigated for each group. Results We found a positive association between cognitive scores and plasma apoE level in both E4 (−) and E4 (+) groups. A positive relationship was also observed between cognitive score and HDL level in the E4 (−) group, but not in the E4 (+) group. No substantial association between cognitive score and LDL, TG, and TC levels was found in either of the groups. Conclusions Our findings suggest that plasma apoE have a positive influence on cognitive function in both E4 (−) and E4 (+) groups, whereas the positive influence of plasma HDL was shown only in E4 (−) group. The identification of the influences of ( APOE ) genotype and the intracellular linkage among apoE and HDL metabolism is hoped for new preventive and therapeutic strategies for cognitive change of elderly. |
| Databáze: | OpenAIRE |
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