Effects of carvedilol therapy on cardiac autonomic control, QT dispersion, and ventricular arrhythmias in children with dilated cardiomyopathy
| Autor: | Mehmet Burhan Oflaz, Ayse Esin Kibar, Volkan Tuzcu, Sevket Balli, İbrahim Ece, Celal Akdeniz |
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| Přispěvatelé: | [Oflaz, Mehmet Burhan] Cumhuriyet Univ, Fac Med, Dept Pediat Cardiol, Sivas, Turkey -- [Balli, Sevket] Ataturk Hosp, Dept Pediat Cardiol, Balikesir, Turkey -- [Kibar, Ayse Esin] Mersin Childrens Hosp, Dept Pediat Cardiol, Mersin, Turkey -- [Ece, Ibrahim] Yuzuncu Yil Univ, Fac Med, Dept Pediat Cardiol, Van, Turkey -- [Akdeniz, Celal -- Tuzcu, Volkan] Istanbul Medipol Univ, Fac Med, Dept Pediat Cardiol Electrophysiol, Istanbul, Turkey, Oflaz, Mehmet Burhan -- 0000-0003-1515-4654, Oflaz, Mehmet Burhan Cumhuriyet Univ, Fac Med, Dept Pediat Cardiol, Sivas, Turkey, Balli, Sevket Ataturk Hosp, Dept Pediat Cardiol, Balikesir, Turkey, Kibar, Ayse Esin Mersin Childrens Hosp, Dept Pediat Cardiol, Mersin, Turkey, Ece, Ibrahim Yuzuncu Yil Univ, Fac Med, Dept Pediat Cardiol, Van, Turkey, Akdeniz, Celal, Tuzcu, Volkan Istanbul Medipol Univ, Fac Med, Dept Pediat Cardiol Electrophysiol, Istanbul, Turkey |
| Rok vydání: | 2013 |
| Předmět: |
Cardiomyopathy
Dilated Male medicine.medical_specialty QT Dispersion Carbazoles Cardiomyopathy Heart Rate Variability carvedilol Autonomic Nervous System Autonomic control Propanolamines Electrocardiography children Clinical Research Heart Rate Internal medicine Idiopathic dilated cardiomyopathy medicine Humans cardiovascular diseases Child Children Dilated Cardiomyopathy medicine.diagnostic_test business.industry heart rate variability Arrhythmias Cardiac Heart Dilated cardiomyopathy General Medicine medicine.disease Carvedilol therapy dilated cardiomyopathy QT dispersion Heart failure Qt dispersion Cardiology Female Carvedilol business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.883911 |
| Popis: | WOS: 000320062000001 PubMed ID: 23686300 Background: The purpose of this study was to examine the effects of carvedilol therapy on autonomic control of the heart and QT-interval dispersion (QTd) among children with idiopathic dilated cardiomyopathy (DCM) whose symptoms were not adequately controlled with standard congestive heart failure therapy. Material/Methods: Patients with DCM who were treated with carvedilol were enrolled in the study. All patients had undergone carvedilol therapy in addition to standard therapy for at least 6 months. Clinical, echocardiographic, and electrocardiographic parameters, and 24-h Holter records of patients were retrospectively evaluated before and after carvedilol treatment. Results: A total 34 patients (mean age: 7.4 +/- 4.3 years) with DCM were analyzed in the study. The median follow-up period was 9.5 months. After the 6 months of carvedilol therapy the clinical score significantly improved, left ventricular ejection fraction (LVEF) and fractional shortening (LVFS) significantly increased, and left ventricle end-diastolic dimensions and end-systolic dimensions significantly decreased. There were statistically significant increases in mean SDNN, SDANN, rMSSD, and pNN50 (p=0.002, p=0.001, p=0.008, and p=0.026, respectively). After the carvedilol therapy, SDNN was correlated with the clinical score, heart rate, LVEF, LVFS, and total premature ventricular contractions (PVCs). In addition, rMSSD and pNN50 were correlated with heart rate, LVEF and LVFS. A significant reduction was observed in QTc-minimum, QTc-maximum, and QTd values (434.9 +/- 40.7 vs. 416.1 +/- 36.5, 497.8 +/- 43.6 vs. 456.3 +/- 41.7, 58.6 +/- 17.1 vs. 49.3 +/- 15.6; p |
| Databáze: | OpenAIRE |
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