REGULATION OF SALT METABOLISM AFTER HYPOPHYSECTOMY IN MAN*†
| Autor: | M. B. Lipsett, O. H. Pearson, M. C. Li, Charles D. West, John P. Maclean |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
Male
medicine.medical_specialty Pituitary gland Hypophysectomy Endocrinology Diabetes and Metabolism Sodium medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Sodium Chloride Biology Biochemistry chemistry.chemical_compound Endocrinology Anterior pituitary Internal medicine medicine Humans Secretion Sodium Chloride Dietary Aldosterone Biochemistry (medical) Sodium Dietary Metabolism medicine.disease medicine.anatomical_structure chemistry Pituitary Gland Diabetes insipidus |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 17:346-355 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-17-3-346 |
| Popis: | THE control of sodium metabolism in the absence of the pituitary gland has not been clearly defined in man. Experiments in patients with panhypopituitarism have been inconclusive because of the variability of anterior pituitary function and the reliance upon inappropriate tests. We shall present our experiences with the hypophysectomized patient subjected to sodium restriction and shall show that sodium conservation remains efficient in the absence of the anterior pituitary gland. There are decisive experimental data in animals (1) which demonstrate normal sodium metabolism after hypophysectomy. The secretion of aldosterone in response to sodium restriction and its relative independence of corticotropin (2) amply explain these findings. Aldosterone excretion has also been shown to be normal in the patient with panhypopituitarism (3) and to increase after hypophysectomy in response to sodium restriction (4). These considerations suggest that adrenal control of sodium metabolismis independent of pituitary f... |
| Databáze: | OpenAIRE |
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