Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients

Autor: Mohammad Krayem, Vu Luan Dang Chi, Soizic Garaud, Karen Willard-Gallo, Catherine Sibille, Mimoune Berehad, Chunyan Gu-Trantien, Jean Nicolas Lodewyckx, Hugues Duvillier, Pushpamali De Silva, Vincent Thibaud, Dominique Bron, Basile Stamatopoulos
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Aging
Cancer Research
Chronic lymphocytic leukemia
Apoptosis
BACH2
0302 clinical medicine
hemic and lymphatic diseases
Gene expression
Positive Regulatory Domain I-Binding Factor 1 -- genetics -- immunology -- metabolism
Lymphocytes
Cellular Senescence
Aged
80 and over
biology
Lymphocyte Subsets -- immunology -- metabolism
Immunosenescence
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Healthy Volunteers
Up-Regulation
Cellular Senescence -- immunology
Basic-Leucine Zipper Transcription Factors
Real-time polymerase chain reaction
Oncology
030220 oncology & carcinogenesis
Female
Untreated Chronic Lymphocytic Leukemia
Research Article
Adult
Down-Regulation -- immunology
Down-Regulation
lcsh:RC254-282
CD19
Young Adult
03 medical and health sciences
PRDM1
Genetics
medicine
Humans
RNA
Messenger
Aged
Leukemia
Lymphocytic
Chronic
B-Cell -- blood -- immunology -- pathology
medicine.disease
Leukemia
Lymphocytic
Chronic
B-Cell
RNA
Messenger -- metabolism
Up-Regulation -- immunology
Lymphocyte Subsets
Aging -- immunology
030104 developmental biology
Basic-Leucine Zipper Transcription Factors -- genetics -- immunology -- metabolism
Immunology
biology.protein
Positive Regulatory Domain I-Binding Factor 1
CD8
Hématologie
Zdroj: BMC cancer, 19 (1
BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
ISSN: 1471-2407
DOI: 10.1186/s12885-019-5276-2
Popis: Age-related genetic changes in lymphocyte subsets are not currently well documented. BACH2 is a transcription factor that plays an important role in immune-mediated homeostasis by tightly regulating PRDM1 expression in both B-cells and T-cells. BACH2 gene expression is highly sensitive to DNA damage in aged mice. This concept led us to investigate the variation in BACH2 and also PRDM1 expression in major lymphocyte subsets with age.
info:eu-repo/semantics/published
Databáze: OpenAIRE
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