Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease
Autor: | Shogo Soma, Heechul Jun, Allen Bramian, Kei M. Igarashi, Takaomi C. Saido, Takashi Saito |
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Rok vydání: | 2019 |
Předmět: |
Male
Neurons General Neuroscience Place cell Hippocampus Grid cell Biology Hippocampal formation Mice Inbred C57BL Amyloid beta-Protein Precursor Mice Medial entorhinal cortex Alzheimer Disease Neural Pathways Brain circuit Amyloid precursor protein biology.protein Connectome Memory impairment Animals Entorhinal Cortex Gamma Rhythm Female Neuroscience CA1 Region Hippocampal |
Zdroj: | Neuron. 107(6) |
ISSN: | 1097-4199 |
Popis: | Patients with Alzheimer's disease (AD) suffer from spatial memory impairment and wandering behavior, but the brain circuit mechanisms causing such symptoms remain largely unclear. In healthy brains, spatially tuned hippocampal place cells and entorhinal grid cells exhibit distinct spike patterns in different environments, a circuit function called "remapping." We tested remapping in amyloid precursor protein knockin (APP-KI) mice with impaired spatial memory. CA1 neurons, including place cells, showed disrupted remapping, although their spatial tuning was only mildly diminished. Medial entorhinal cortex (MEC) neurons severely lost their spatial tuning and grid cells were almost absent. Fast gamma oscillatory coupling between the MEC and CA1 was also impaired. Mild disruption of MEC grid cells emerged in younger APP-KI mice, although the spatial memory and CA1 remapping of the animals remained intact. These results point to remapping impairment in the hippocampus, possibly linked to grid cell disruption, as circuit mechanisms underlying spatial memory impairment in AD. |
Databáze: | OpenAIRE |
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