Scanning Electron Microscopic Hair Shaft Analysis in Ectodermal Dysplasia Syndromes
| Autor: | Stefanie A. Hirano-Ali, Timothy Sorrells, Kimberly Salkey, David M. Pariser, Ashley M. Reed, J B S Brandon Rowan, Antoinette F. Hood, Judith V. Williams |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ectodermal dysplasia Adolescent Hair shaft Hair shaft abnormalities Dermatology Sensitivity and Specificity Severity of Illness Index Cohort Studies Ectodermal Dysplasia Reference Values Severity of illness medicine Humans Child integumentary system Ectodermal Dysplasia Syndromes business.industry Case-control study Infant Syndrome Control subjects medicine.disease Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Microscopy Electron Scanning Female business Hair Follicle Hair Cohort study |
| Zdroj: | Pediatric Dermatology. 32:836-844 |
| ISSN: | 0736-8046 |
| Popis: | Objectives The objective of the current study was to catalog hair shaft abnormalities in individuals with ectodermal dysplasia (ED) syndromes using scanning electron microscopy (SEM) and to compare the findings with those in unaffected controls. This is the second of a two-part study, the first of which used light microscopy as the modality and was previously published. Methods Scanning electron microscopy was performed in a blinded manner on hair shafts from 65 subjects with seven types of ED syndromes and 41 unaffected control subjects. Assessment was performed along the length of the shaft and in cross section. Setting Hair donations were collected at the 28th Annual National Family Conference held by the National Foundation for Ectodermal Dysplasia. Control subjects were recruited from a private dermatology practice and an academic children's hospital outpatient dermatology clinic. Results SEM identified various pathologic hair shaft abnormalities in each type of ED and in control patients. When hairs with all types of ED were grouped together and compared with those of control patients, the difference in the presence of small diameter and shallow and deep grooves was statistically significant (p |
| Databáze: | OpenAIRE |
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