CAMcog as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education
| Autor: | Orestes Vicente Forlenza, Marcia Radanovic, Izabella Dutra de Abreu, Mônica Sanches Yassuda, Paula Villela Nunes, Danilo T. Borelli, Breno S. Diniz |
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| Rok vydání: | 2008 |
| Předmět: |
Gerontology
Male Pediatrics medicine.medical_specialty Psychometrics Neuropsychological Tests Sensitivity and Specificity mental disorders medicine Dementia Verbal fluency test Humans Mass Screening Neuropsychological assessment Aged Aged 80 and over Psychiatric Status Rating Scales medicine.diagnostic_test Cognitive disorder Memory clinic Neuropsychological test Middle Aged medicine.disease Psychiatry and Mental health Early Diagnosis ROC Curve Area Under Curve Educational Status Female Geriatrics and Gerontology Alzheimer's disease Psychology Cognition Disorders Brazil |
| Zdroj: | International journal of geriatric psychiatry. 23(11) |
| ISSN: | 1099-1166 |
| Popis: | Background The CAMCOG is a brief neuropsychological battery designed to assess global cognitive function and ascertain the impairments that are required for the diagnosis of dementia. To date, the cut-off scores for mild cognitive impairment (MCI) have not been determined. Given the need for an earlier diagnosis of mild dementia, new cut-off values are also necessary, taking into account cultural and educational effects. Methods One hundred and fifty-seven older adults (mean age: 69.6 ± 7.4 years) with 8 or more years of formal education (mean years of schooling 14.2 ± 3.8) attending a memory clinic at the Institute of Psychiatry University of Sao Paulo were included. Subjects were divided into three groups according to their cognitive status, established through clinical and neuropsychological assessment: normal controls, n = 62; MCI, n = 65; and mild or moderate dementia, n = 30. ROC curve analyses were performed for dementia vs controls, MCI vs controls and MCI vs dementia. Results The cut-off values were: 92/93 for dementia vs controls (AUC = 0.99: sensitivity: 100%, specificity: 95%); 95/96 for MCI vs controls (AUC = 0.83, sensitivity: 64%, specificity: 88%), and 85/86 for MCI vs dementia (AUC = 0.91, sensitivity: 81%, specificity: 88%). The total CAMCOG score was more accurate than its subtests Mini-mental State Examination, Verbal Fluency Test and Clock Drawing Test when used separately. Conclusions The CAMCOG discriminated controls and MCI from demented patients, but was less accurate to discriminate MCI from controls. The best cut-off value to differentiate controls and demented was higher than suggested in the original publication, probably because only cases of mild to moderate dementia were included. This is important given the need for a diagnostic at earlier stages of Alzheimer's disease. Copyright © 2008 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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