Actinic granuloma of the conjunctiva in young women
| Autor: | Ruchi Mittal, Debarati Saha, Meena Mk |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Conjunctiva Ultraviolet Rays Stain Conjunctival Diseases Diagnosis Differential Young Adult Granuloma Giant Cell medicine Humans Young adult Retrospective Studies Geography Neovascularization Pathologic business.industry Actinic keratosis medicine.disease Dermatology Ophthalmology Actinic granuloma medicine.anatomical_structure Giant cell Granuloma Sunlight Female Differential diagnosis business |
| Zdroj: | Ophthalmology. 120(9) |
| ISSN: | 1549-4713 |
| Popis: | Objective To report the occurrence of actinic granuloma of the conjunctiva in young women. Design Retrospective case series. Participants Three eyes of 3 young women with a unilateral conjunctival mass of recent onset. Methods Three young women (21, 23, and 23 years of age) sought treatment for painless red masses of the conjunctiva that were thought clinically to be pingueculitis, actinic keratosis, or ocular surface squamous neoplasia (OSSN), but were diagnosed histopathologically as actinic granuloma. Special stains were performed to exclude infectious and autoimmune causes of granulomatous inflammation, followed by dermatologic work-up and systemic investigations. Diagnosis of actinic granuloma of the conjunctiva was confirmed. Main Outcome Measures Patients' characteristics (age, sex, early onset), clinical presentation, same geographical location, typical histopathologic features, and lack of systemic association. Results All 3 cases were in young women with a rapid-onset conjunctival growth with conjunctival feeder vessels and intrinsic vessels; however, there was no surface keratin, and rose bengal stain results were negative. Histopathologic analysis of all 3 cases revealed elastolysis and granulomatous inflammation characterized by multinucleated giant cells, some of which displayed elastophagocytosis that was highlighted by Verhoeff-van Giesen elastic stain. There was absence of cytologic atypia of surface epithelium. Mucin stains and special stains for an infectious cause demonstrated negative results. Serologic investigations and systemic work-up results were negative, which excluded any systemic associations with this condition. This led to the final diagnoses of actinic granuloma of the conjunctiva. Conclusions Conjunctival actinic granuloma is an underrecognized entity. We present 3 cases of this condition to highlight its occurrence in young women and the role of histopathologic examination to avoid misinterpretation of this condition. Both clinician and pathologist should consider this entity as a differential diagnosis of benign conjunctival lesions and OSSN. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article. |
| Databáze: | OpenAIRE |
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