Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia
| Autor: | Jennifer L. Bakalar, Anand Mattai, Nitin Gogtay, Eric M. Wassermann, Judith L. Rapoport, Christopher N. David, Rachel Miller, Brian Weisinger, Julia W. Tossell, Deanna Greenstein |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Population Biophysics Prefrontal Cortex Electric Stimulation Therapy Neuropsychological Tests Article law.invention lcsh:RC321-571 Superior temporal gyrus Randomized controlled trial law medicine Humans childhood-onset schizophrenia education Psychiatry Child lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Psychiatric Status Rating Scales education.field_of_study dorsolateral prefrontal cortex Transcranial direct-current stimulation General Neuroscience medicine.disease Magnetic Resonance Imaging Transcranial Magnetic Stimulation Dorsolateral prefrontal cortex Transcranial magnetic stimulation medicine.anatomical_structure Tolerability Schizophrenia Anesthesia Female Neurology (clinical) transcranial direct current stimulation Psychology Schizophrenia Childhood Follow-Up Studies |
| Zdroj: | Brain Stimulation, Vol 4, Iss 4, Pp 275-280 (2011) |
| Popis: | Background In recent years, transcranial direct current stimulation (tDCS) has been used to study and treat many neuropsychiatric conditions. However, information regarding its tolerability in the pediatric population is lacking. Objective This study aims to investigate the tolerability aspects of tDCS in the childhood-onset schizophrenia (COS) population. Methods Twelve participants with COS completed this inpatient study. Participants were assigned to one of two groups: bilateral anodal dorsolateral prefrontal cortex (DLPFC) stimulation (n = 8) or bilateral cathodal superior temporal gyrus (STG) stimulation (n = 5). Patients received either 2 mA of active treatment or sham treatment (with possibility of open active treatment) for 20 minutes, for a total of 10 sessions (2 weeks). Results tDCS was well tolerated in the COS population with no serious adverse events occurring during the study. Conclusions This is the first study to demonstrate that a 20-minute duration of 2 mA of bilateral anodal and bilateral cathodal DC polarization to the DLPFC and STG was well tolerated in a pediatric population. |
| Databáze: | OpenAIRE |
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