Endosomes, lysosomes: their implication in gene transfer
| Autor: | Simone Wattiaux-De Coninck, Robert Wattiaux, Nathanael Laurent, Michel Jadot |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Endosome
Endocytic cycle Genetic Vectors Gene Transfer Techniques Pharmaceutical Science Transfection DNA Endosomes Biology Endocytosis Cell biology chemistry.chemical_compound Plasmid medicine.anatomical_structure Biochemistry chemistry Transcription (biology) Lysosome medicine Animals Humans Lysosomes |
| Zdroj: | Advanced drug delivery reviews. 41(2) |
| ISSN: | 0169-409X |
| Popis: | Plasmid DNA, naked or bound to a non-viral vector, is taken up by endocytosis. As a result, it has to travel through the intracellular endocytic pathway involving endosomes and lysosomes. However, some DNA molecules must escape these organelles to reach the nucleus where transcription takes place. In this paper, we consider different factors that could affect the trafficking of plasmid DNA and influence transfection efficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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