Ischemia modified albumin in normal pregnancy and preeclampsia

Autor:	J. Marko Sikkema, Hein W. Bruinse, Bas B. van Rijn, Herman J.M. van Rijn, Arie Franx, Hieronymus A.M. Voorbij
Rok vydání:	2008
Předmět:	Adult medicine.medical_specialty Placenta Ischemia medicine.disease_cause Gastroenterology Preeclampsia Pre-Eclampsia Pregnancy Internal medicine Albumins Internal Medicine medicine Humans reproductive and urinary physiology business.industry Ischemia-modified albumin Albumin Obstetrics and Gynecology medicine.disease medicine.anatomical_structure Case-Control Studies Immunology Biomarker (medicine) Female business Oxidative stress Biomarkers
Zdroj:	Hypertension in pregnancy. 27(2)
ISSN:	1525-6065
Popis:	Ischemia-modified albumin (IMA) has emerged as a new biomarker of myocardial ischemia. Currently, no information is available on maternal IMA levels during normal and complicated pregnancy. Preeclampsia is associated with ischemia and increased formation of free radicals in the placenta. We therefore hypothesized that production of IMA may occur in women with preeclampsia.Serum IMA and albumin concentrations were assessed in 12 patients with preeclampsia, 12 normal pregnant controls, and 12 nonpregnant controls. IMA levels were compared between groups and corrected for albumin by multivariate regression analysis.Mean IMA levels were elevated in normal pregnant controls (107.3 U/mL; 95% CI, 102.5 to 112.01), compared with nonpregnant controls (94.5 U/mL; CI, 89.4 to 99.6; p = 0.015). In patients with preeclampsia, IMA levels were similar to those in normal pregnant controls (109.7 U/mL; CI, 102.2 to 117.2; p = 0.65). Also, no difference in IMA levels was observed between women with preeclampsia who delivered small-for-gestational-age (SGA) infants (99.0 U/mL; CI, 87.9 to 110.1; p = 0.13) and women with preeclampsia but without SGA.Serum IMA, which has been advocated as a clinical marker of cardiac ischemia, appears to be elevated during normal pregnancy. We found no significant relationship between IMA levels and preeclampsia, in women with or without SGA infants.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4bc66b57b54c5d1bcedbd27c091433 https://pubmed.ncbi.nlm.nih.gov/18484421 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.