Lymphocytic Hypophysitis in a Man Presenting with Hypercalcemia
| Autor: | Cynthia Williams, Marcia E. Cornford, Louis Novoa-Takara, John A. Tayek |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Respiratory distress Hypophysitis business.industry Pituitary Diseases Autopsy General Medicine Middle Aged Hypoglycemia medicine.disease Gastroenterology Pneumonia Endocrinology Diabetes Mellitus Type 2 Internal medicine Hypercalcemia medicine Adrenal insufficiency Humans Lymphocytes Hyponatremia Complication business |
| Zdroj: | The American Journal of the Medical Sciences. 321:206-208 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/00000441-200103000-00011 |
| Popis: | A 59-year-old man with a 30-year history of type 2 diabetes mellitus presented with fatigue, confusion, and weight loss over a 3-month period. He was found to be hypercalcemic (11.8 mg/dL) and dehydrated, and his hypercalcemia improved with intravenous fluids. While in the hospital, he developed hyponatremia, hypoglycemia, and hypotension. He was found to have a subnormal cortisol level of 2.3 microg/dL at baseline, which increased to only 5.6 microg/dL 60 minutes after a 250-microg corticotropin intravenous stimulation test. The patient developed pneumonia and adult respiratory distress syndrome and died of an acute myocardial infarction. During the autopsy, he was found to have lymphocytic hypophysitis with a severe reduction in corticotropin-producing anterior pituitary cells. No malignancy was identified at autopsy. He is the first male patient to be described in the literature who presented with hypercalcemia caused by lymphocytic hypophysitis. |
| Databáze: | OpenAIRE |
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