Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens
| Autor: | Tsutomu Yamashita, Shintaro Ochi, Hisataka Fujimoto, Yasushi Inoue, Junichi Kiryu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Refractive error Aqueous solution Chemistry thin aqueous layer break Silicones Biomedical Engineering Water Hydrogels Silicone hydrogel Contact Lenses Hydrophilic medicine.disease Article contact lenses Contact lens Ophthalmology Tears Tear meniscus height medicine silicone hydrogel-soft contact lens water gradient structure tear film Lens crystalline |
| Zdroj: | Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Popis: | Purpose Soft contact lenses (SCLs) are effective for refractive error correction, but prolonged wear triggers discomfort and discontinuation. This study investigates whether water gradient technology of delefilcon A-based SCLs improve tear film dynamics. Methods This retrospective observational study included 50 asymptomatic delefilcon A or narafilcon A users. Data on thin aqueous layer break (TALB; %), noninvasive tear break-up time (NIBUT), tear meniscus height (TMH; mm), subjective dryness, and higher-order aberrations (HOAs) were collected. Measurements of the bare eye, the SCL-worn eye after 15 minutes (visit 1 [v1]) and 30 ± 5 days after v1 after SCL was worn for ≥5 hours (visit 2 [v2]) were recorded. Results TALB was significantly reduced in the delefilcon A group compared to the narafilcon A group (33.3% vs. 85.5% at v1; P < 0.0001 and 31.7% vs. 80.4% at v2; P < 0.0001). The NIBUT was also significantly higher in the former (4.2 ± 2.1 seconds vs. 2.9 ± 1.5 at v1; P < 0.01 and 4.1 ± 2.3 seconds vs. 2.7 ± 1.6 seconds at v2; P < 0.01) across both visits. The TMH was significantly reduced in the former in both v1 and v2. The total ocular HOAs were significantly lower in the former at v1 (P < 0.001) and v2 (P < 0.05) compared to the bare eye. Conclusions The water gradient technology of delefilcon A reduces TALB and increases NIBUT. Translational Relevance The use of water gradient technology improves tear film dynamics and alleviate pathological break-up pattern, improving lens performance. |
| Databáze: | OpenAIRE |
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