Anisotropic Polytetrafluoroethylene Cardiovascular Conduits Spontaneously Expand in a Growing Lamb Model
| Autor: | Yuriy Moklyak, Richard W. Bianco, John P. Carney, Anthony Azakie, Matthew T. Lahti |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Heart Defects
Congenital medicine.medical_specialty Heart Ventricles Pulmonary Artery 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine.artery medicine Animals Humans Polytetrafluoroethylene Retrospective Studies Bioprosthesis Sheep business.industry Infant Cardiac surgery Treatment Outcome medicine.anatomical_structure chemistry Ventricle 030220 oncology & carcinogenesis Pulmonary artery Cardiology 030211 gastroenterology & hepatology Surgery business |
| Zdroj: | Journal of Investigative Surgery. 34:1348-1354 |
| ISSN: | 1521-0553 0894-1939 |
| DOI: | 10.1080/08941939.2020.1805056 |
| Popis: | Insertion of conduits from the right ventricle (RV) to the pulmonary artery (PA) is a commonly used technique for repair of congenital heart defects. The vast majority of infants and children will require reoperation and/or re-intervention to replace the conduit. Some children may require multiple reoperations, with the risk of death and morbidity increasing significantly with each subsequent operation. We evaluated the feasibility and performance of a relatively novel anisotropic conduit for cardiovascular repair in the growing lamb model.Lambs were allocated into a control (Control conduits did not expand, all 3 animals developed one or more adverse events including tachypnea, ascites, inappetence, lethargy, and mortality due to severe right heart failure and significantly higher peak trans-conduit gradients (48.5 ± 5.1 p = 0.02). The test conduits spontaneously expanded up to 14.8 ± 0.8 mm in diameter, no adverse events were observed in any animals and trans-conduit gradients were significantly lower (27.0 ± 8.3, p = 0.02).Anisotropic ePTFE conduits can be safely implanted in growing lambs with stable hemodynamics. This spontaneously expanding anisotropic conduit may represent a novel approach to congenital heart repairs that would avoid the need for reoperation or multiple operations. |
| Databáze: | OpenAIRE |
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