Reverse ventricular remodelling after cardiac resynchronization therapy is associated with a reduction in serum tenascin-C and plasma matrix metalloproteinase-9 levels
| Autor: | Marleen H. M. Hessel, Gabe B. Bleeker, Douwe E. Atsma, Maureen M. Henneman, Arnoud van der Laarse, Brigit den Adel, Jeroen J. Bax, M.J. Schalij, Margreet Klok |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Heart Ventricles medicine.medical_treatment Cardiac resynchronization therapy Tenascin Matrix metalloproteinase Ventricular Dysfunction Left Internal medicine Natriuretic Peptide Brain Humans Medicine Prospective Studies cardiovascular diseases Ventricular remodeling Prospective cohort study Aged Ventricular Remodeling biology business.industry Tenascin C Cardiac Pacing Artificial Middle Aged medicine.disease Brain natriuretic peptide Peptide Fragments Extracellular Matrix Treatment Outcome Matrix Metalloproteinase 9 Heart failure biology.protein Cardiology Matrix Metalloproteinase 2 Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | European Journal of Heart Failure. 9:1058-1063 |
| ISSN: | 1388-9842 |
| Popis: | Background: In heart failure patients, cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling. Aim: The aim of this study was to evaluate whether changes in levels of circulating biomarkers of extracellular matrix metabolism correlate with the response to CRT. Methods and results: Clinical parameters, left ventricular (LV) volumes, and circulating levels of tenascin-C (TNC), matrix metalloproteinase-2 (MMP-2), MMP-9, and amino-terminal propeptide of brain natriuretic peptide (NT-proBNP) were assessed in 64 patients at baseline and 6 months follow-up. The majority of patients (72%) showed a >10% reduction in LV end-systolic volume at follow-up, and were classified as responders to CRT. The remaining patients were classified as non-responders. In responders, a significant decrease in circulating levels of TNC (from 60±40ng/mL to 47±30ng/mL, p |
| Databáze: | OpenAIRE |
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