Urinary Volatile Organic Compounds as Potential Biomarkers in Idiopathic Membranous Nephropathy
| Autor: | Xibei Jia, Mingao Wang, Rujuan Xie, Ruichan Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male China medicine.medical_specialty Urinary system 030232 urology & nephrology Urine 030204 cardiovascular system & hematology Glomerulonephritis Membranous Gastroenterology Gas Chromatography-Mass Spectrometry 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans In patient Aged Principal Component Analysis Volatile Organic Compounds Original Paper medicine.diagnostic_test business.industry General Medicine Middle Aged Idiopathic Membranous Nephropathy Case-Control Studies Potential biomarkers Female Gas chromatography Renal biopsy Gas chromatography–mass spectrometry business Biomarkers |
| Zdroj: | Medical Principles and Practice. 26:375-380 |
| ISSN: | 1423-0151 1011-7571 |
| Popis: | Objective: To detect urinary volatile organic compounds (VOCs) in patients with idiopathic membranous nephropathy (iMN) and normal controls, and to examine whether or not urinary VOCs can act as biomarkers for the diagnosis of iMN independent of renal biopsy. Materials and Methods: Gas chromatography/mass spectrometry (GC/MS) was used to assess the urine collected from 63 iMN patients and 15 normal controls. The statistical methods of principal component analysis and partial least squares discriminant analysis were performed to process the final data in Common Data Format which were converted from GC/MS data. Results: Six VOCs in the urine samples of iMN patients exhibited significant differences from those of normal controls: carbamic acid monoammonium salt, 2-pentanone, 2,4-dimethyl-pentanal, hydrogen azide, thiourea, and 4-heptanone were significantly higher than in controls (p < 0.05). Conclusions: Six urinary VOCs were isolated from patients with iMN using GC/MS. The analysis of urinary VOCs using GC/MS could be developed into a non-invasive method for the detection of iMN. |
| Databáze: | OpenAIRE |
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