Role of the thyrotropin-releasing hormone stimulation test in diagnosis of congenital central hypothyroidism in infants
| Autor: | Thomas Vulsma, David A. van Tijn, Jan J. M. de Vijlder |
|---|---|
| Přispěvatelé: | Other Research, Paediatric Endocrinology |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyrotropin Thyrotropin-releasing hormone Biochemistry Statistics Nonparametric Cohort Studies Endocrinology TRH stimulation test Adrenocorticotropic Hormone Internal medicine Congenital Hypothyroidism medicine Central hypothyroidism Humans Prospective Studies Thyrotropin-Releasing Hormone Hydrocortisone Human Growth Hormone business.industry Biochemistry (medical) Neuroglycopenia Thyroid Infant Newborn Infant medicine.disease Magnetic Resonance Imaging Prolactin Congenital hypothyroidism IGSF1 Thyroxine medicine.anatomical_structure Area Under Curve Triiodothyronine Female business Gonadotropins hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of clinical endocrinology and metabolism, 93(2), 410-419. The Endocrine Society |
| ISSN: | 0021-972X |
| DOI: | 10.1210/jc.2006-2656 |
| Popis: | Context: A shortage of thyroid hormone during prenatal life and the first years after birth results in a spectrum of neuropsychological disorders, depending on the duration and severity of the deficiency. In the case of congenital hypothyroidism of central origin (CH-C), the majority of patients have multiple pituitary hormone deficiencies (MPHD). This condition poses an additional threat to postnatal central nervous system development, primarily on account of neuroglycopenia due to ACTH/cortisol deficiency with or without additional GH deficiency. Therefore, in CH-C, rapid diagnosis is even more urgent than in congenital hypothyroidism of thyroidal origin.Objective: In the assessment of hypothalamic-pituitary-thyroid function, we considered the pituitary response to iv administration of TRH (TRH test) pivotal. We evaluated the usefulness of the TRH test in a cohort of infants with neonatal congenital hypothyroidism screening results indicative of CH-C by analyzing the results within the framework of investigations of the anatomical and functional integrity of the hypothalamo-hypophyseal system.Design and Setting: The study was a Dutch nationwide prospective study (1994–1996). Patients were included if neonatal congenital hypothyroidism screening results were indicative of CH-C and patients could be tested within 3 months of birth.Patients: Ten male and five female infants with CH-C, detected by neonatal screening, and six infants with false-positive screening results, nonthyroidal illness, or transient hypothyroidism, were included in the study.Main Outcome Measures: Results of TRH tests, within the framework of extensive endocrinological examinations and cerebral magnetic resonance imaging, were measured.Results: All patients with type 3 TSH responses to TRH had MPHD, and the majority (67%) of patients with type 2 responses had isolated TSH deficiency.Conclusions: The TRH test has a pivotal role in the diagnosis of TSH deficiency in young infants. Abnormal TRH test results, especially a type 3 response, urge immediate assessment of integral hypothalamic-pituitary function because the majority of patients have MPHD. |
| Databáze: | OpenAIRE |
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