Expression of transforming growth factor-β receptor type 1 and type 2 in human sporadic vestibular Schwannoma
| Autor: | Bernd Freigang, Knut Dietzmann, Christian Mawrin, Kathrin Chamaon, Mathias Löttrich, Elmar Kirches |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty TGF alpha Reverse Transcriptase Polymerase Chain Reaction Cell Biology Biology Endoglin Immunohistochemistry Pathology and Forensic Medicine Schwann cell proliferation medicine.anatomical_structure Peripheral nervous system Vestibulocochlear Nerve Diseases otorhinolaryngologic diseases medicine biology.protein Humans Cranial Nerve Neoplasms RNA Messenger Receptor Receptors Transforming Growth Factor beta Neurilemmoma Transforming growth factor Neurotrophin |
| Zdroj: | Pathology - Research and Practice. 203:245-249 |
| ISSN: | 0344-0338 |
| Popis: | Expression of the transforming growth factor-beta (TGF-beta) protein family in the peripheral nervous system is well established, but the role of their cognate receptors TGF-beta receptor type 1 (R1) and type 2 (R2) has been less well studied. TGF-beta plays an essential role in Schwann cell proliferation and differentiation, and is involved in neurotrophic effects of several neurotrophic substances. TGF-beta is also expressed in benign peripheral nervous system tumors such as vestibular schwannomas. In the present study, we aimed to detect TGF-beta R1 and R2 in a total of 40 sporadic vestibular schwannomas using immunohistochemistry, and correlated the findings to essential clinicopathologic data. TGF-beta, TGF-beta R1, and TGF-beta R2 mRNA was further analyzed by RT-PCR in six vestibular schwannomas. TGF-beta R1 immunoexpression was found in about 95% of the tumors. TGF-beta R1 was equally present in Antoni A and Antoni B areas of the tumors. TGF-beta R2 was found immunohistochemically in 77%. In addition, all tumors showed strong expression of TGF-beta. No correlation between TGF-beta R1 or R2 expression and clinicopathologic parameters such as age, sex, clinical symptoms, growth pattern, and proliferation acitivity as measured by Ki-67 (MIB-1) staining was found. Moreover, all schwannomas studied contained TGF-beta, TGF-beta R1, and TGF-beta R2 mRNA. Therefore, the TGF-beta/TGF-beta R1 and -R2 system is present in human schwannomas, but its biologic role for tumor development and growth remains unclear. |
| Databáze: | OpenAIRE |
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