Risk of stomach cancer in Aotearoa/New Zealand: A Māori population based case-control study

Autor: Soo Cheng, Neil Pearce, Andrew Sporle, Jonathan Koea, Lis Ellison-Loschmann, Michelle Gray, Tracey Whaanga, Pauline Harawira, Parry Guilford, Marine Corbin
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Native Hawaiian or Other Pacific Islander
lcsh:Medicine
Pathology and Laboratory Medicine
Habits
0302 clinical medicine
Endocrinology
Animal Products
Risk Factors
Helicobacter
Medicine and Health Sciences
Smoking Habits
Odds Ratio
Stomach cancer
lcsh:Science
education.field_of_study
Multidisciplinary
Alcohol Consumption
biology
Incidence (epidemiology)
Cancer Risk Factors
Incidence
Stomach
Agriculture
Middle Aged
Aotearoa
Bacterial Pathogens
Oncology
Medical Microbiology
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
Anatomy
Pathogens
Research Article
medicine.medical_specialty
Meat
Endocrine Disorders
Population
Microbiology
03 medical and health sciences
Breast cancer
Diagnostic Medicine
Stomach Neoplasms
medicine
Diabetes Mellitus
Cancer Detection and Diagnosis
Humans
education
Microbial Pathogens
Nutrition
Aged
Behavior
Bacteria
business.industry
lcsh:R
Organisms
Biology and Life Sciences
Odds ratio
Helicobacter pylori
biology.organism_classification
medicine.disease
Helicobacter Pylori
Surgery
Cancer registry
Diet
Gastrointestinal Tract
Logistic Models
Food
Metabolic Disorders
Case-Control Studies
lcsh:Q
business
Digestive System
Demography
New Zealand
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181581 (2017)
ISSN: 1932-6203
Popis: Māori, the indigenous people of New Zealand, experience disproportionate rates of stomach cancer, compared to non-Māori. The overall aim of the study was to better understand the reasons for the considerable excess of stomach cancer in Māori and to identify priorities for prevention. Māori stomach cancer cases from the New Zealand Cancer Registry between 1 February 2009 and 31 October 2013 and Māori controls, randomly selected from the New Zealand electoral roll were matched by 5-year age bands to cases. Logistic regression was used to estimate odd ratios (OR) and 95% confidence intervals (CI) between exposures and stomach cancer risk. Post-stratification weighting of controls was used to account for differential non-response by deprivation category. The study comprised 165 cases and 480 controls. Nearly half (47.9%) of cases were of the diffuse subtype. There were differences in the distribution of risk factors between cases and controls. Of interest were the strong relationships seen with increased stomach risk and having >2 people sharing a bedroom in childhood (OR 3.30, 95%CI 1.95-5.59), testing for H pylori (OR 12.17, 95%CI 6.15-24.08), being an ex-smoker (OR 2.26, 95%CI 1.44-3.54) and exposure to environmental tobacco smoke in adulthood (OR 3.29, 95%CI 1.94-5.59). Some results were attenuated following post-stratification weighting. This is the first national study of stomach cancer in any indigenous population and the first Māori-only population-based study of stomach cancer undertaken in New Zealand. We emphasize caution in interpreting the findings given the possibility of selection bias. Population-level strategies to reduce the incidence of stomach cancer in Māori include expanding measures to screen and treat those infected with H pylori and a continued policy focus on reducing tobacco consumption and uptake.
Databáze: OpenAIRE
Externí odkaz: