Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination

Autor: Richard Tuli, Erminia Massarelli, Andrew Eugene Hendifar, Thang Q. Le, Jun Gong
Rok vydání: 2018
Předmět:
0301 basic medicine
Oncology
Cancer Research
medicine.medical_treatment
Programmed Cell Death 1 Receptor
Review
Mice
Clinical trials
0302 clinical medicine
Neoplasms
Checkpoint inhibitor
PD-1
Immunology and Allergy
Medicine
Cancer
biology
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Combined Modality Therapy
Preclinical
Radiation therapy
5.1 Pharmaceuticals
030220 oncology & carcinogenesis
Molecular Medicine
Development of treatments and therapeutic interventions
Programmed death
PD-L1
medicine.medical_specialty
Immunology
lcsh:RC254-282
03 medical and health sciences
Internal medicine
Animals
Humans
Immune response
Pharmacology
Radiotherapy
Animal
business.industry
Clinical study design
Antitumor
Immunotherapy
Preclinical data
Blockade
Clinical trial
Disease Models
Animal
030104 developmental biology
Disease Models
biology.protein
business
Zdroj: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-17 (2018)
Journal for immunotherapy of cancer, vol 6, iss 1
ISSN: 2051-1426
Popis: Several inhibitors of programmed cell death-1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved as a form of immunotherapy for multiple cancers. Ionizing radiation therapy (RT) has been shown to enhance the priming and effector phases of the antitumor T-cell response rendering it an attractive therapy to combine with PD-1/PD-L1 inhibitors. Preclinical data support the rational combination of the 2 modalities and has paved way for the clinical development of the combination across a spectrum of cancers. In this review, we highlight the preclinical and clinical development of combined RT and PD-1/PD-L1 blockade to date. In addition to a comprehensive evaluation of available safety and efficacy data, we discuss important points of consideration in clinical trial design for this promising combination.
Databáze: OpenAIRE
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