The predictive value of serum progesterone and 17-OH progesterone levels on in vitro fertilization outcome
| Autor: | Eric A. Widra, Michael J. Levy, Arthur W. Sagoskin, Denise L. Murray, David B. Smotrich, Jerry L. Hall |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Ovulation medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Radioimmunoassay Serum progesterone Fertilization in Vitro Biology Chorionic Gonadotropin Ovarian Follicle Predictive Value of Tests Pregnancy Internal medicine 17-OH Progesterone Genetics medicine Hydroxyprogesterones Humans Genetics (clinical) Progesterone In vitro fertilisation 17-alpha-Hydroxyprogesterone Obstetrics and Gynecology General Medicine Predictive value Pregnancy rate Endocrinology Reproductive Medicine Predictive value of tests Female Developmental Biology |
| Zdroj: | Journal of assisted reproduction and genetics. 12(3) |
| ISSN: | 1058-0468 |
| Popis: | In order to identify parameters which predict prognosis for success with in vitro fertilization, 17-hydroxyprogesterone and progesterone levels were evaluated in 254 patients undergoing 296 in vitro fertilization cycles. Selected response and outcome data were recorded.Patients with intermediate values of serum progesterone (0.7-0.8 ng/ml) at the time of human chorionic gonadotropin administration achieved significantly higher pregnancy rates than patients with lower (0.7 ng/ml) or higher (0.8 ng/ml) levels. The clinical pregnancy rates were 46%, 31%, and 27% respectively (P = 0.02). There was no change in 17-hydroxyprogesterone concentration which predicted a higher pregnancy rate.Excellent clinical pregnancy rates were noted in cycles with a progesterone level of 0.7-0.8 ng/ml, as well as good results in cycles above 0.8 ng/ml. There is therefore no reason to administer human chorionic gonadotropin at a smaller follicle size to prevent a rise in serum progesterone. |
| Databáze: | OpenAIRE |
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