Macrolide resistance in Mycoplasma genitalium from female sex workers in Belgium
| Autor: | Patrick Descheemaeker, Luk Bingé, Jerina Boelens, Elizaveta Padalko, Marijke Reynders, Liselotte Coorevits, Ans Traen |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Microbiology (medical) 030106 microbiology Immunology Mycoplasma genitalium Microbiology Young Adult 03 medical and health sciences 0302 clinical medicine Bacterial Proteins Belgium Drug Resistance Bacterial Humans Immunology and Allergy Mycoplasma Infections Prospective Studies 030212 general & internal medicine Sex Workers biology Female sex biology.organism_classification Virology Anti-Bacterial Agents Macrolide resistance Mutation Female Macrolides |
| Zdroj: | Journal of Global Antimicrobial Resistance. 12:149-152 |
| ISSN: | 2213-7165 |
| DOI: | 10.1016/j.jgar.2017.09.018 |
| Popis: | Mycoplasma genitalium is emerging as an aetiological agent of sexually transmitted infections (STIs). Although M. genitalium is commonly treated with azithromycin, macrolide resistance associated with point mutations in the 23S rRNA gene is emerging.In this study, the prevalence of M. genitalium and macrolide resistance in female sex workers (FSW) in Belgium was evaluated by a prospective study conducted between 2015 and 2016. Vaginal swabs were sampled from 303 FSW who underwent testing for M. genitalium along with standard STI screening. All samples positive for M. genitalium were subsequently tested for mutations associated with macrolide resistance.M. genitalium was detected in 10.8% of participants and macrolide resistance-associated mutations (A2058G and A2059G) were found in 6.5% of isolates.M. genitalium is clearly present in FSW in Belgium. In contrast to other reports, for now the occurrence of macrolide resistance appears limited in this specific target population. |
| Databáze: | OpenAIRE |
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